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739979

Sigma-Aldrich

Resomer® RG 858 S, Poly(D,L-lactide-co-glycolide)

ester terminated, lactide:glycolide 85:15, Mw 190,000-240,000

Sinónimos:

PLGA

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About This Item

Fórmula lineal:
[C3H4O2]x[C2H2O2]y
Número de CAS:
26780-50-7
UNSPSC Code:
12162002
NACRES:
NA.23

Quality Level

100

form

amorphous

feed ratio

lactide:glycolide 85:15

mol wt

Mw 190,000-240,000

degradation timeframe

<9 months

viscosity

1.3-1.7 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

storage temp.

2-8°C

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

General description

RESOMER® polymers are bioresorbable aliphatic polyesters comprised of a range of different ratios of lactide and glycolide monomers, PLA stereochemistries, and end-group functionalization. These biodegradeable homopolymers and copolymers of lactide and glycolide afford a variety of properties that range from very stiff, hard semi-crystalline materials with long degradation times, to softer, amorphous materials with faster degradation rates.

Application

Controlled release
Electrospun Resomer® X 206 S blended with cellulose from bagasse can be used as a scaffold in tissue engineering.

Features and Benefits

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

Legal Information

Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
MKCW7933
MKCV5197
BCCG7417
BCCF7604
BCCC6904

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RESOMER??Biodegradeable Polymers for Sutures, Medical Devices, Drug Delivery Systems and Tissue Engineering
Mader K
Material Matters, 6(3), 62-62 (2011)
Maria Kirzhner et al.
Ophthalmology, 120(6), 1300-1304 (2013-02-13)
To compare wrapped and polymer-coated hydroxyapatite implants in children undergoing primary enucleation with no adjuvant therapies. Retrospective, interventional cohort study. All children undergoing primary enucleation without adjuvant therapies between 1999 and 2009 at a tertiary pediatric cancer hospital. Review and
Igor Jeroukhimov et al.
Journal of the American College of Surgeons, 218(1), 102-107 (2013-11-12)
Chronic pain after inguinal hernia repair occurs in 16% to 62% of patients. The underlying mechanism probably involves sensory nerve damage and abnormal healing that might be influenced by the materials chosen for the procedure. We hypothesize that nonabsorbable sutures
Teresa Musumeci et al.
International journal of pharmaceutics, 440(2), 135-140 (2012-10-20)
Melatonin, a neurohormone secreted by the pineal gland, is able to modulate intraocular pressure (IOP). The aim of this study was to generate nanoparticle (NPs) sustained release formulations that allow to extend the pre-corneal residence time of melatonin, thus prolonging
Kyle E Broaders et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(14), 5497-5502 (2009-03-27)
Materials that combine facile synthesis, simple tuning of degradation rate, processability, and biocompatibility are in high demand for use in biomedical applications. We report on acetalated dextran, a biocompatible material that can be formed into microparticles with degradation rates that
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