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465119

Sigma-Aldrich

Baicalein

98%

Sinónimos:

5,6,7-Trihydroxyflavone

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About This Item

Fórmula empírica (notación de Hill):
C15H10O5
Número de CAS:
491-67-8
Peso molecular:
270.24
Beilstein:
272683
Número MDL:
MFCD00017459
Código UNSPSC:
12352100
ID de la sustancia en PubChem:
24870246
NACRES:
NA.22

Nivel de calidad

100

Ensayo

98%

Formulario

solid

mp

256-271 °C (lit.)

grupo funcional

ketone
phenyl

cadena SMILES

Oc1cc2OC(=CC(=O)c2c(O)c1O)c3ccccc3

InChI

1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H

Clave InChI

FXNFHKRTJBSTCS-UHFFFAOYSA-N

Información sobre el gen

mouse ... Hexa(15211)
rat ... Alox15(81639) , Alox5(25290)

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Descripción general

Baicalein, a flavonoid, is a xanthine oxidase inhibitor. Anti-inflammatory effects of baicalein in peripheral human leukocytes has been studied.

Aplicación

Baicalein was used in a study to investigate the in vitro quantitative inhibition of lipoxygenase.

Acciones bioquímicas o fisiológicas

The flavonoid component of Nepalese and Sino-Japanese crude drugs. Baicalein, a major flavone of Scutellariae baicalensis, inhibits the 12-lipoxygenase (12-LOX) pathway of arachidonic acid metabolism, which inhibits cancer cell proliferation and induces apoptosis.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
MKCX1335
MKCR0734
0000195123
0000239789
0000195123

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Candidone ≥95% (LC/MS-ELSD)

Sigma-Aldrich

SMB00135

Candidone

Scutellarein ≥98% (HPLC)

Sigma-Aldrich

S0327

Scutellarein

Chrysin ≥96.5%

Sigma-Aldrich

C80105

Chrysin

Wogonin hydrate ≥98% (HPLC), solid

Sigma-Aldrich

W0769

Wogonin hydrate

D E Shieh et al.
Anticancer research, 20(5A), 2861-2865 (2000-11-04)
Xanthine oxidase inhibitors are known to be therapeutically useful for the treatment of hepatitis and brain tumor. Baicalein, baicalin and wogonin, isolated from Scutellaria rivularis, have been reported to exhibit a strong activity on xanthine oxidase inhibition. In this study
Nina M Høyland-Kroghsbo et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(1), 131-135 (2016-11-17)
CRISPR-Cas are prokaryotic adaptive immune systems that provide protection against bacteriophage (phage) and other parasites. Little is known about how CRISPR-Cas systems are regulated, preventing prediction of phage dynamics in nature and manipulation of phage resistance in clinical settings. Here
Yefei Zhou et al.
Poultry science, 98(7), 2790-2799 (2019-02-20)
Baicalein, the main flavonoid extracted from the root of Scutellaria baicalensis Georgi, has been demonstrated to exert multiple pharmacological effects, and thus could be utilized as a potential feed additive in broiler chickens. This study evaluated the effects of broiler
Naheed Riaz et al.
Phytochemistry, 65(8), 1129-1135 (2004-04-28)
Paeoninol and paeonin C, oligostilbene and monoterpene galactoside, have been isolated from the methanolic extract of the fruits of Paeonia emodi. Their structures have been assigned on the basis of spectral analysis including 1D and 2D NMR techniques. In addition
Yuh-Chiang Shen et al.
European journal of pharmacology, 465(1-2), 171-181 (2003-03-26)
To evaluate the possible mechanisms responsible for the anti-inflammatory effects of baicalin or baicalein, phorbol-12-myristate-13-acetate (PMA)- or N-formyl-methionyl-leucyl-phenylalanine (fMLP)-activated inflammatory responses of peripheral human leukocytes were studied. Both baicalin and baicalein diminished fMLP- or PMA-induced reactive oxygen intermediates production in
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