463485
Methyl isonipecotate
technical grade
Sinónimos:
Methyl 4-piperidinecarboxylate
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About This Item
Fórmula empírica (notación de Hill):
C7H13NO2
Número de CAS:
Peso molecular:
143.18
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Productos recomendados
grade
technical grade
Quality Level
refractive index
n20/D 1.465 (lit.)
bp
85-90 °C (lit.)
density
1.06 g/mL at 25 °C (lit.)
SMILES string
COC(=O)C1CCNCC1
InChI
1S/C7H13NO2/c1-10-7(9)6-2-4-8-5-3-6/h6,8H,2-5H2,1H3
InChI key
RZVWBASHHLFBJF-UHFFFAOYSA-N
Categorías relacionadas
General description
Methyl isonipecotate can be obtained by the reduction of methyl isonicotinate in methanol with ruthenium at 100-150°C.
Application
Methyl isonipecotate may be used for the synthesis of a series of potent non-urea soluble epoxide hydrolase (sEH) inhibitors via high throughput screens.
Precipitate may form upon standing which should not affect application.
Reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation
Reactant for synthesis of:
Antitubercular agents
Anti-HIV-1 agents
Aminopyrazine inhibitors
Orally available naphthyridine protein kinase D inhibitors
A Scalable catalyst from asymmetric hydrogenation of sterically demanding aryl enamide
Reactant for synthesis of:
Antitubercular agents
Anti-HIV-1 agents
Aminopyrazine inhibitors
Orally available naphthyridine protein kinase D inhibitors
A Scalable catalyst from asymmetric hydrogenation of sterically demanding aryl enamide
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
192.2 °F - closed cup
flash_point_c
89 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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Yuli Xie et al.
Bioorganic & medicinal chemistry letters, 19(8), 2354-2359 (2009-03-24)
Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC(50)s of the most potent compounds
The Reaction of Calcium with Pyridine and Its Methyl Derivatives1.
Utke AR and Sanderson RT.
The Journal of Organic Chemistry, 28(12), 3582-3584 (1963)
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