457698

(R)-(+)-2-Methyl-CBS-oxazaborolidine solution

1 M in toluene

• Sinónimos: α,α-Diphenyl-D-prolinolmethylboronic acid cyclamide ester, (R)-1-Methyl,3,3-diphenyl-tetrahydro-pyrrolo(1,2-c)(1,3,2)oxazaborole, (R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole
• Fórmula empírica (notación de Hill): C₁₈H₂₀BNO
• Número de CAS: 112022-83-0
• Peso molecular: 277.17
• Número MDL: MFCD00078440
• Código UNSPSC: 12352005
• ID de la sustancia en PubChem: 24869385
• NACRES: NA.22

Propiedades

• concentración: 1 M in toluene
• bp: 111 °C
• densidad: 0.95 g/mL at 25 °C
• grupo funcional: phenyl
• temp. de almacenamiento: room temp
• cadena SMILES: [H][C@]12CCCN1B(C)OC2(c3ccccc3)c4ccccc4
• InChI: 1S/C18H20BNO/c1-19-20-14-8-13-17(20)18(21-19,15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17H,8,13-14H2,1H3/t17-/m1/s1
• Clave InChI: VMKAFJQFKBASMU-QGZVFWFLSA-N

Descripción

Aplicación

CBS Catalysts for Asymmetric Reduction and Asymmetric Synthesis

(R)-(+)-2-Methyl-CBS-oxazaborolidine solution [1M in toluene] may be used as a catalyst in the asymmetric borane reduction of perfluoroalkyl ketones.
It may also be used in the preparation of:

• (-)-diospongin B
• (1R)-2-azido-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol
• (S)-α-deuteriobenzyl alcohol
• (3S,4R,5S)-1-(trimethylsilyl)-4,5-epoxyhex-1-yn-3-ol

Excellent catalyst of asymmetric reductions.

The CBS (Corey-Bakshi-Shibata) oxazaborolidine catalyst has been used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C₂ symmetrical ferrocenyl diols, and propargyl alcohols.
Used in a desymmetrizing reduction leading to (S)-4-hydroxycyclohexenone.

Forma física

Precipitate may form in storage, but does not affect product quality. Gently heat product to 80−90 °C under an inert atmosphere to redissolve solids.

Información de seguridad

• Pictogramas: GHS02,GHS08,GHS05,GHS07
• Palabra de señalización: Danger
• Frases de peligro: H225,H304,H315,H318,H336,H361d,H373,H412
• Consejos de prudencia: P210 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P331
• Clasificaciones de peligro: Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 - STOT SE 3
• Órganos de actuación: Central nervous system
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): 39.2 °F - closed cup
• Punto de inflamabilidad (°C): 4 °C - closed cup
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter