112208

4-Nitrobenzoyl chloride

98%

• Sinónimos: p-Nitrobenzoyl chloride
• Fórmula lineal: O₂NC₆H₄COCl
• Número de CAS: 122-04-3
• Peso molecular: 185.56
• Beilstein/REAXYS Number: 473192
• EC Number: 204-517-4
• MDL number: MFCD00007345
• UNSPSC Code: 12352100
• PubChem Substance ID: 24847076
• NACRES: NA.22

Propiedades

• Quality Level: 200
• assay: 98%
• form: solid
• bp: 202-205 °C/105 mmHg (lit.)
• mp: 71-74 °C (lit.)
• functional group: acyl chloride; nitro
• SMILES string: [O-][N+](=O)c1ccc(cc1)C(Cl)=O
• InChI: 1S/C7H4ClNO3/c8-7(10)5-1-3-6(4-2-5)9(11)12/h1-4H
• InChI key: SKDHHIUENRGTHK-UHFFFAOYSA-N

Descripción

General description

4-Nitrobenzoyl chloride reacts with triphenylphosphonium salt to synthesize benzofurans (potential positron emission tomography (PET) tracers) by the intramolecular Wittig reaction.It has been used for the derivatisation of Adiol (Androstenediol, an endogenous proliferation agent of prostate cancer).

Application

<ul>
<li><strong>Automated Synthesis of [11C]PiB:</strong> 4-Nitrobenzoyl chloride is utilized in the automated synthesis of [11C]PiB, a radiopharmaceutical for PET imaging of amyloid, highlighting its role in enhancing neuroimaging techniques (Singh et al., 2024).</li>
</ul>

Información de seguridad

• pictograms: GHS05
• signalword: Danger
• hcodes: H290,H314
• pcodes: P234 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 1
• flash_point_f: 215.6 °F - closed cup
• flash_point_c: 102 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges