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Key Documents

SAB4300674

Sigma-Aldrich

Anti-phospho-Tyrosine Hydroxylase (pSer31) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-TH, Anti-Tyrosine 3-hydroxylase, Anti-Tyrosine 3-monooxygenase

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

55-60 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(V-T-Sp-P-R)

NCBI accession no.

NM_000360.3

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer31)

Gene Information

human ... TH(7054)

General description

The antibody detects endogenous levels of Tyrosine Hydroxylase only when phosphorylated at serine 31.

Immunogen

Peptide sequence around phosphorylation site of serine31 (V-T-Sp-P-R), according to the protein NP_000351.2

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Plays an important role in the physiology of adrenergic neurons.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alán Alpár et al.
The EMBO journal, 37(21) (2018-09-14)
Stress-induced cortical alertness is maintained by a heightened excitability of noradrenergic neurons innervating, notably, the prefrontal cortex. However, neither the signaling axis linking hypothalamic activation to delayed and lasting noradrenergic excitability nor the molecular cascade gating noradrenaline synthesis is defined.
Scot McIntosh et al.
Frontiers in psychiatry, 4, 88-88 (2013-08-24)
Chronic cocaine administration regulates the expression of several proteins related to dopaminergic signaling and synaptic function in the mesocorticolimbic pathway, including the prefrontal cortex. Functional abnormalities in the prefrontal cortex are hypothesized to be due in part to the expression
András H Lékó et al.
Scientific reports, 7(1), 3396-3396 (2017-06-15)
Adaptation to motherhood includes maternal behaviour and lactation during the postpartum period. The major organizing centres of maternal behaviour and lactation are located in the hypothalamic medial preoptic area (MPOA) and the arcuate nucleus, respectively. Insulin-like growth factor I (IGF-I)
Rita Matuska et al.
Brain structure & function, 225(3), 969-984 (2020-03-23)
Chronic hypernatremia activates the central osmoregulatory mechanisms and inhibits the function of the hypothalamic-pituitary-adrenal (HPA) axis. Noradrenaline (NE) release into the periventricular anteroventral third ventricle region (AV3V), the supraoptic (SON) and hypothalamic paraventricular nuclei (PVN) from efferents of the caudal

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