M2383

α-(Methylamino)isobutyric acid

≥97% (titration)

• Synonym(s): 2,N-Dimethylalanine, 2-(Methylamino)-2-methylpropionic acid
• Linear Formula: CH₃NHC(CH₃)₂COOH
• CAS Number: 2566-34-9
• Molecular Weight: 117.15
• Beilstein: 1746984
• EC Number: 219-898-2
• MDL number: MFCD00004191
• UNSPSC Code: 12352209
• PubChem Substance ID: 24896726
• NACRES: NA.26

Properties

• Assay: ≥97% (titration)
• form: powder
• technique(s): ligand binding assay: suitable
• color: white
• mp: >300 °C (lit.)
• storage temp.: −20°C
• SMILES string: CNC(C)(C)C(O)=O
• InChI: 1S/C5H11NO2/c1-5(2,6-3)4(7)8/h6H,1-3H3,(H,7,8)
• InChI key: DLAMVQGYEVKIRE-UHFFFAOYSA-N

Description

Application

α-(Methylamino)isobutyric acid (MeAIB) has been used:

• as a system A transport system inhibitor to perform inhibition experiments
• as a system A transport system inhibitor to study its effect on the generation of epileptiform field potentials (EFPs) in the acutely disinhibited cortical slices
• as an N-acetyltransferase (SNAT) inhibitor in Hank′s balanced salt solution (HBSS) to study its influence on the uptake of ¹⁴C-cysteine/ radioactive-labeled cysteine

Biochem/physiol Actions

α-(Methylamino)isobutyric acid (MeAIB), a competitive inhibitor of the neutral amino acid transport A system, is an N-methylated substrate. It is capable of decreasing the amplitude of the miniature excitatory postsynaptic current (mEPSC) in hippocampus neurons developing on top of astrocytes. MeAIB can block the alanine-proline (AP) pathway.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H319
• Precautionary Statements: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves