H0266
Hemoglobin A2, Ferrous Stabilized human
lyophilized powder
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About This Item
CAS Number:
EC Number:
MDL number:
UNSPSC Code:
12352202
eCl@ss:
42030116
NACRES:
NA.61
Recommended Products
biological source
human
Quality Level
Assay
97-100% (agarose gel electrophoresis)
form
lyophilized powder
technique(s)
immunofluorescence: suitable
suitability
suitable for electrophoresis and chromatography standard
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... HBA2(3040)
General description
Hemoglobin A2 (HBA2) is mapped to human chromosome 16p13.3. HBA2 is a minor hemoglobin component and comprises of two α and δ chains.
Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.
has not been tested for functional equivalence against native preparations (unlyophilized ferrous hemoglobins).
Application
Hemoglobin A2 was used in the determination of fetal hemoglobin by time-resolved immunofluorometric assay.
Hemoglobin A2, Ferrous Stabilized human has been used as a reference in reversed-phase high-performance liquid chromatography for quantifying δ-globin elution profile. It has also been used as calibrator in isotope dilution mass spectrometry (IDMS) measurements.
Biochem/physiol Actions
Elevated levels of Hemoglobin A2 (HBA2) is observed in patients with β-thalassemia trait.
Packaging
Package size indicates the amount of hemoglobin as determined by the procedure of Drabkin, D.L., J. Biol. Chem., 164, 703 (1946).
Reconstitution
When reconstituted with buffer, gives >90% ferrous hemoglobin.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Elevated hemoglobin A2 as a marker for beta-thalassemia trait in pregnant women
Ou Z, et al.
The Tohoku Journal of Experimental Medicine, 223(3), 223-226 (2011)
Saqib Hussain Ansari et al.
JPMA. The Journal of the Pakistan Medical Association, 62(12), 1314-1317 (2013-07-23)
To screen immediate family members of thalassaemia patients for carrier identification and counselling. The cross-sectional study was conducted at an urban thalassaemia treatment and prevention centre in Karachi, Pakistan, from January to December 2008, and involved 188 siblings of 100
Rapid and Sensitive Assessment of Globin Chains for Gene and Cell Therapy of Hemoglobinopathies
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Human Gene Therapy Methods, 29(1), 60-74 (2018)
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Pediatric hematology and oncology, 29(5), 472-478 (2012-08-08)
Iron deficiency (IDA) and beta thalassemia trait (TT) are the most common causes of hypochromia and microcytosis. Many indices have been defined to quickly discriminate these similar entities via parameters obtained from automated blood cell analyzers. However, studies in the
Determination of HbA2 by quantitative bottom-up proteomics and isotope dilution mass spectrometry
Arsene C, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 487, 318-324 (2018)
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