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Toltrazuril sulfone

VETRANAL®, analytical standard

Synonym(s):

1-Methyl-3-{3-methyl-4-[4-(trifluoromethylsulfonyl)phenoxy]phenyl}-1,3,5-triazine-2,4,6(1H,3H,5H)-trione

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About This Item

Empirical Formula (Hill Notation):
C18H14F3N3O6S
CAS Number:
Molecular Weight:
457.38
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CN1C(=O)NC(=O)N(C1=O)c2ccc(Oc3ccc(cc3)S(=O)(=O)C(F)(F)F)c(C)c2

InChI

1S/C18H14F3N3O6S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)30-12-4-6-13(7-5-12)31(28,29)18(19,20)21/h3-9H,1-2H3,(H,22,25,26)

InChI key

VBUNOIXRZNJNAD-UHFFFAOYSA-N

General description

Toltrazuril sulfone is an antiprotozoal agent, which belongs to the group of triazines. It is highly effective against apicomplexan group of organisms.

Application

Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Toltrazuril sulfone may be used as a reference standard in the determination of toltrazuril sulfone in food samples using fast liquid chromatography coupled with tandem mass spectrometry (LC-MS-MS).

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Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Pharmacokinetics of toltrazuril and its metabolites, toltrazuril sulfoxide and toltrazuril sulfone, after a single oral administration to pigs.
Lim HJ, et al.
The Journal of Veterinary Medical Science, 72(8), 1085-1087 (2010)
Detection, quantifications and pharmacokinetics of toltrazuril sulfone ([TM="Ponazuril"]) in cattle.
Dirikolu L, et al.
Journal of Veterinary Pharmacology and Therapeutics, 32(3), 280-288 (2009)
Anna Martínez-Villalba et al.
Analytical and bioanalytical chemistry, 397(7), 2893-2901 (2010-07-27)
In this work a fast liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method was developed for the analysis of toltrazuril, a coccidiostatic drug, and its metabolites in meat food products. The applicability of atmospheric pressure chemical ionization (APCI) and heated electrospray
Janis Rusko et al.
Journal of pharmaceutical and biomedical analysis, 164, 402-412 (2018-11-16)
A new sensitive and selective multi-residue method based on liquid chromatography - Orbitrap high resolution mass spectrometry (LC-Orbitrap-HRMS) was developed and validated for the determination of 17 anticoccidials in poultry and eggs. Instrumental parameters were optimized by the means of

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