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  • Sulfonylation of quinoline N-oxides with aryl sulfonyl chlorides via copper-catalyzed C-H bonds activation.

Sulfonylation of quinoline N-oxides with aryl sulfonyl chlorides via copper-catalyzed C-H bonds activation.

Organic letters (2013-03-07)
Zhiyong Wu, Hongyu Song, Xiuling Cui, Chao Pi, Weiwei Du, Yangjie Wu
ABSTRACT

An efficient and concise one-pot protocol to synthesize sulfonylated quinoline N-oxides via copper-catalyzed C-H bond activation has been developed. Commercially available and less expensive aryl sulfonyl chlorides were used as the sulfonylation reagents. Various 2-aryl sulfonyl quinolines were obtained in up to 91% yields in chemo- and regioselective manners.

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Sulfuryl chloride, 97%
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Sulfuryl chloride solution, 1.0 M in methylene chloride
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