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Key Documents

SRP6374

Sigma-Aldrich

Galectin-9 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(s):

Ecalectin, Gal-9, LGALS9, Tumor antigen HOM-HD-21

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

form

liquid

mol wt

18.5 kDa (168 aa, 1-148 aa + His Tag.)

packaging

pkg of 50 μg

concentration

0.5 mg/mL

UniProt accession no.

O00182

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... LGALS9(3965)

General description

Galectin-9 (Gal-9) is a member of animal lectins that have an affinity to β-galactosides and Forssman pentasaccharide. It is strongly overexpressed in Hodgkin′s disease tissue and it might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its consistently associated immunodeficiency. Recombinant Galectin-9 protein was expressed in E.coli and purified by using conventional chromatography techniques.

Physical form

0.5 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM NaCl and 20% glycerol.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Rina Nakajima et al.
Journal of dermatological science, 96(3), 134-142 (2019-12-04)
Galectin-9, a member of the galectin family, can promote tumor growth through inducing apoptosis in anti-tumor immune cells via T cell immunoglobulin and mucin domain 3 (TIM-3). On the other hand, galectin-9 also induces tumor cell apoptosis in many malignancies
Gaia Nebbia et al.
PloS one, 7(10), e47648-e47648 (2012-11-01)
The S-type lectin galectin-9 binds to the negative regulatory molecule Tim-3 on T cells and induces their apoptotic deletion or functional inactivation. We investigated whether galectin-9/Tim-3 interactions contribute to the deletion and exhaustion of the antiviral T cell response in
Si-Na Kim et al.
Immune network, 15(5), 241-251 (2015-11-12)
Bone marrow-derived mesenchymal stem cells (MSCs) have immunomodulatory properties and can suppress exaggerated pro-inflammatory immune responses. Although the exact mechanisms remain unclear, a variety of soluble factors are known to contribute to MSC-mediated immunosuppression. However, functional redundancy in the immunosuppressive
Gisela M Vaitaitis et al.
PloS one, 7(6), e38708-e38708 (2012-06-12)
While it has long been understood that CD40 plays a critical role in the etiology of autoimmunity, glycobiology is emerging as an important contributor. CD40 signaling is also gaining further interest in transplantation and cancer therapies. Work on CD40 signaling
Susanna Leskela et al.
PloS one, 10(4), e0123938-e0123938 (2015-04-17)
Patients with autoimmune thyroid disease (AITD) show defects in their immune-regulatory mechanisms. Herein we assessed the expression and function of galectin-1 and galectin-9 (Gal-1, Gal-9) in dendritic cells (DCs) from patients with AITD. Peripheral blood samples from 25 patients with
View All Related Papers

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