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Key Documents

SML3476

Sigma-Aldrich

Brivaracetam

≥98% (HPLC)

Synonym(s):

(αS,4R)-α-Ethyl-2-oxo-4-propyl-1-pyrrolidineacetamide, (2S)-2-[(4R)-2-Oxo-4-propylpyrrolidin-1-yl]butanamide, (S)-2-((R)-2-Oxo-4-propylpyrrolidin-1-yl)butanamide, UCB 34714, UCB-34714, UCB34714

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About This Item

Empirical Formula (Hill Notation):
C11H20N2O2
CAS Number:
Molecular Weight:
212.29
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

drug control

USDEA Schedule V

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

-10 to -25°C

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Biochem/physiol Actions

Brivaracetam shows approximately 10 times greater potency than levetiracetam (Keppra)*; pIC50 at LBS = 7.0; inhibits audiogenic seizures in seizure-prone mice (ED50 = 14 μmol/kg) and is also effective in other animal models of epilepsy. Brivaracetam is used as an anticonvulsant (antiepileptic) for seizure treatment.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Brivaracetam attenuates pain behaviors in a murine model of neuropathic pain
Molecular Pain (2019)
Discovery of 4-substituted pyrrolidone butanamides as new agents with significant antiepileptic activity
Journal of medicinal chemistry, 47(3), 530-549 (2004)
Brivaracetam is superior to levetiracetam in a rat model of post-hypoxic myoclonus
Journal of neural transmission (Vienna, Austria : 1996), 114(12), 1547-1551 (2007)

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