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About This Item
Empirical Formula (Hill Notation):
C35H40N6O11
Molecular Weight:
720.73
UNSPSC Code:
12352202
NACRES:
NA.32
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product name
Caspase Substrate,
Assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥80%
storage condition
protect from light
storage temp.
−20°C
Amino Acid Sequence
Z-Tyr-Val-Ala-Asp-pNA
Application
Z-YVAD-pNa (Z-Tyr-Val-Ala-Asp-pNA) is used as a caspase 1 substrate.
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Overlapping cleavage motif selectivity of caspases: implications for analysis of apoptotic pathways.
G P McStay et al.
Cell death and differentiation, 15(2), 322-331 (2007-11-03)
Caspases orchestrate the controlled demise of a cell after an apoptotic signal through specific protease activity and cleavage of many substrates altering protein function and ensuring apoptosis proceeds efficiently. Comparing a variety of substrates of each apoptotic caspase (2, 3
A Eckert et al.
Journal of neuroscience research, 64(2), 183-192 (2001-04-05)
The Swedish double mutation (KM670/671NL) of amyloid precursor protein (APPsw) is associated with early-onset familial Alzheimer's disease (FAD) and results in from three- to sixfold increased beta-amyloid production. The goal of the present study was to elucidate the effects of
Natasha Ann Pereira et al.
Biochemical and biophysical research communications, 377(3), 873-877 (2008-11-04)
Many designated substrates and inhibitors have been widely used to investigate the roles of caspases in apoptotic death during mammalian cell culture. However, the specificities of these substrates and inhibitors have not been systematically evaluated. As a result, conclusions on
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