SAB4502971

Anti-TIMP1 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): COLLAGENASE INHIBITOR, EPA, HCI, HUMAN, tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity
• MDL number: MFCD01322705
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 23 kDa
• species reactivity: mouse, human, rat
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:10000; western blot: 1:500-1:1000
• NCBI accession no.: P01033
• UniProt accession no.: P01033
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... TIMP1(7076)

Description

General description

The TIMP1 (TIMP metallopeptidase inhibitor 1) gene is mapped to human chromosome Xp11.3.

Tissue inhibitors of metalloproteinase 1 (TIMP1) is a member of TIMPs protein family. It is widely expressed in most of the human tissues and body fluids. TIMP1 is a wedge shaped protein with five β-strands, a central helical region representing the interface of the two domains and a C-terminal β-structure.

Immunogen

The antiserum was produced against synthesized peptide derived from human TIMP1.

Immunogen Range: 61-110

Application

Anti-TIMP1 antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

TIMP1 (TIMP metallopeptidase inhibitor 1) mediates the communication between tumor cells and cancer associated fibroblasts and contributes to tumor progression in condition such as hepatocellular carcinoma. The encoded protein is a cytokine tissue inhibitor. Timp1 regulates the activity of matrix metalloproteinases (MMP) especially MMP-8 and -9. Imbalance in Timp1 levels lowers the fibrotic material in the extracellular matrix and results in inflammation. This might contribute to the pathogenesis of myocardial fibrosis, atherosclerosis and acute coronary syndrome. Timp1 level serves as an important biomarker in the development of sepsis.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable