SAB4200420

Anti-Lamin A, mature antibody, Mouse monoclonal

clone 4A4, purified from hybridoma cell culture

• Synonym(s): Anti-LMN1, Anti-LMNA, Anti-Lamin A/C, Anti-Prelamin-A/C, Monoclonal Anti-Lamin A, mature antibody produced in mouse
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• Quality Level: 200
• conjugate: unconjugated
• antibody form: purified from hybridoma cell culture
• antibody product type: primary antibodies
• clone: 4A4, monoclonal
• form: buffered aqueous solution
• mol wt: antigen ~72 kDa
• species reactivity: human
• enhanced validation: independent; Learn more about Antibody Enhanced Validation
• concentration: ~1.0 mg/mL
• technique(s): indirect immunofluorescence: 0.25-0.5 μg/mL using human HeLa cells; western blot: 0.25-0.5 μg/mL using whole extracts of human HeLa cells
• isotype: IgG1
• UniProt accession no.: P02545
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... LMNA(4000)

Description

General description

Lamin A is encoded by the gene with exons 1–12, mapped on human chromosome 1q21-22. The encoded protein is a major component of the inner nuclear membrane lamina. Lamin A is expressed in variety of tissues, including adult heart and skeletal muscle.

Immunogen

synthetic peptide corresponding to the C-terminus of mature human Lamin A.

Application

Monoclonal Anti-Lamin A, mature antibody produced in mouse has been used in immunohistochemistry.

Biochem/physiol Actions

Lamin A can be used as a biomarker for cancer diagnosis and prognosis. It also plays a major role in maintaining cardiac homeostasis. Mutation in the gene is associated with Emery-Dreifuss muscular dystrophy (EDMD-AD) and Hutchinson–Gilford progeria syndrome (HGPS). In addition, variation in the gene expression also leads to various disorders such as, lipodystrophy, progeria, muscular dystrophy, neuropathy and cardiomyopathy.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable