P8477
Picotamide
Synonym(s):
4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide
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About This Item
Empirical Formula (Hill Notation):
C21H20N4O3
CAS Number:
Molecular Weight:
376.41
EC Number:
MDL number:
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.83
Recommended Products
Assay
≥98%
Quality Level
form
powder
solubility
ethanol: 50 mg/mL, clear, colorless to light yellow
SMILES string
COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3
InChI
1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)
InChI key
KYWCWBXGRWWINE-UHFFFAOYSA-N
Gene Information
human ... TBXA2R(6915)
Biochem/physiol Actions
Eicosenoid receptor antagonist; a thromboxane A2 antagonist; antiplatelet agent.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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W Van Molle et al.
FEBS letters, 467(2-3), 201-205 (2000-02-17)
Tumor necrosis factor (TNF) induces hepatitis when injected in human beings or in rodents. The molecular mechanism by which TNF induces hepatic distress remains largely unknown, although induction of apoptosis of hepatocytes appears to be an essential step. In order
P L Malini et al.
Lancet (London, England), 350(9070), 15-18 (1997-07-05)
The increased prostaglandin synthesis that might follow stimulation of the arachidonic acid cascade by angiotensin-converting-enzyme inhibition (ACE-I) has been suggested to underlie the appearance of cough on ACE-I treatment. We investigated whether the prostanoid thromboxane was involved. Nine patients with
Matthew Hotston et al.
BJU international, 106(11), 1794-1798 (2010-05-27)
To explore the possible role of of 8-isoprostane F(2α) (8-IPF(2α) ) in the aetiology of erectile dysfunction (ED), as the over-production of superoxide (O(2)(-)) derived from nicotinamide adenine dinucleotide phosphate (NADPH) oxidase results in the formation of 8-IPF(2α) in vascular
M Berrettini et al.
European journal of clinical pharmacology, 39(5), 495-500 (1990-01-01)
Picotamide (G 137), a new non prostanoid inhibitor of in vitro arachidonic acid induced platelet aggregation, has been further characterized in in vitro and ex vivo studies. When whole blood was activated with collagen in the presence of picotamide 5
P Pancera et al.
Journal of internal medicine, 242(5), 373-376 (1998-01-04)
To assess the role of thromboxane A2 and of angiotensin II in patients with primary Raynaud's phenomenon. After an eight-day run-in period, the patients were enrolled in a single-blind, cross-over, study. Patients were examined at the Ambulatory for Microcirculatory Diseases
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