L6293

LY-364947

≥98% (HPLC)

• Synonym(s): 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]-quinoline, HTS 466284, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor
• Empirical Formula (Hill Notation): C₁₇H₁₂N₄
• CAS Number: 396129-53-6
• Molecular Weight: 272.30
• MDL number: MFCD00800758
• UNSPSC Code: 51111800
• PubChem Substance ID: 24724526
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: c1ccc(nc1)-c2n[nH]cc2-c3ccnc4ccccc34
• InChI: 1S/C17H12N4/c1-2-6-15-13(5-1)12(8-10-19-15)14-11-20-21-17(14)16-7-3-4-9-18-16/h1-11H,(H,20,21)
• InChI key: IBCXZJCWDGCXQT-UHFFFAOYSA-N
• Gene Information: human ... TGFBR1(7046)

Description

Biochem/physiol Actions

LY-364947 is a selective, ATP-competitive inhibitor of Transforming Growth Factor-β Type I receptor kinase (TGF-β RI, ALK5) with IC₅₀ = 59 nM. It is much less potent at related kinases, with IC₅₀ = 400 nM for TGF-β RII and IC₅₀ = 1400 nM for mixed lineage kinase-7 (MLK-7), a kinase in the MAP kinase signal pathway and closely related to TGF-β RII. LY-364947 inhibits TGF-β-dependent cellular growth (IC₅₀ = 81 nM) in NIH 3T3 mouse fibroblasts.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves