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Cathepsin G from human leukocytes

Name: Cathepsin G from human leukocytes
Brand: SIGMA

lyophilized powder, ≥60 units/mg protein (Bradford)

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About This Item

CAS Number:

107200-92-0

EC Number:

3.4.21.20 (BRENDA, IUBMB)

UNSPSC Code:

12352200

NACRES:

NA.32

MDL number:

MFCD00130750

Specific activity:

≥60 units/mg protein (Bradford)

Biological source:

human leucocytes

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Properties

biological source

human leucocytes

Quality Segment

200

form

lyophilized powder

specific activity

≥60 units/mg protein (Bradford)

mol wt

23-30 kDa

UniProt accession no.

P08311

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... CTSG(1511)

Description

General description

Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12.

Application

Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage.

Biochem/physiol Actions

Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.

Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.

Physical form

Lyophilized from 0.5 M pyridinium acetate, pH 5.3.

Other Notes

One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.

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This Item	C8571	C0150	SRP0289
Sigma-Aldrich C4428 Cathepsin G from human leukocytes	Sigma-Aldrich C8571 Cathepsin B from human liver	Sigma-Aldrich C0150 Cathepsin B from human placenta	Sigma-Aldrich SRP0289 Cathepsin B Active human
description lyophilized powder, ≥60 units/mg protein (Bradford)	description buffered aqueous solution, ≥200 units/mg protein (One unit is defined as the amount of enzyme that hydrolyzes 1 μmol of Z-Arg-Arg-beta-naphthylamide per minute at 40 °C, using 100 mM Na/K phosphate, pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.)	description lyophilized powder, ≥5 units/mg protein	description recombinant, expressed in FreeStyle^™ 293-F cells, ≥90% (SDS-PAGE)
Gene Information human ... CTSG(1511)	Gene Information human ... CTSB(1508)	Gene Information human ... CTSB(1508)	Gene Information human ... CTSB(1508)
biological source human leucocytes	biological source human liver	biological source -	biological source human
specific activity ≥60 units/mg protein (Bradford)	specific activity ≥200 units/mg protein (One unit is defined as the amount of enzyme that hydrolyzes 1 μmol of Z-Arg-Arg-beta-naphthylamide per minute at 40 °C, using 100 mM Na/K phosphate, pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.)	specific activity ≥5 units/mg protein	specific activity ≥2228 pmol/min-μg
form lyophilized powder	form buffered aqueous solution	form lyophilized powder	form aqueous solution
mol wt 23-30 kDa	mol wt -	mol wt 24.5 kDa	mol wt 43 kDa
UniProt accession no. P08311	UniProt accession no. P07858	UniProt accession no. P07858	UniProt accession no. -

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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