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N-Methyl-N-trimethylsilylheptafluorobutyramide

for GC derivatization, LiChropur™, ≥90% (GC)

Synonym(s):

N-Trimethylsilyl-N-methylheptafluorobutyramide, MSHFBA

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About This Item

Linear Formula:
CF3CF2CF2CON(CH3)Si(CH3)3
CAS Number:
53296-64-3
Molecular Weight:
299.26
Beilstein:
6512894
MDL number:
MFCD00077822
UNSPSC Code:
12000000
PubChem Substance ID:
329761696
NACRES:
NA.22

grade

for GC derivatization

Quality Level

100

Assay

≥90% (GC)

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.353 (lit.)
n20/D 1.353

bp

148 °C (lit.)

density

1.254 g/mL at 25 °C (lit.)

SMILES string

CN(C(=O)C(F)(F)C(F)(F)C(F)(F)F)[Si](C)(C)C

InChI

1S/C8H12F7NOSi/c1-16(18(2,3)4)5(17)6(9,10)7(11,12)8(13,14)15/h1-4H3

InChI key

CMXKINNDZCNCEI-UHFFFAOYSA-N

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Application


  • Simultaneous quantitation of cocaine, opiates, and their metabolites in human hair by positive ion chemical ionization gas chromatography-mass spectrometry: This study demonstrates the application of N-Methyl-N-trimethylsilylheptafluorobutyramide in forensic toxicology to analyze drug residues in human hair, providing a robust method for detecting such compounds at trace levels (Höld KM, Wilkins DG, Rollins DE, Joseph RE Jr, Cone EJ, 1998).

  • Detection of stanozolol in hair by negative ion chemical ionization mass spectrometry: The research utilizes N-Methyl-N-trimethylsilylheptafluorobutyramide for the sensitive detection of stanozolol, a performance-enhancing steroid, in hair samples. This method is particularly useful in sports doping analyses to ensure fair play (Höld KM, Wilkins DG, Crouch DJ, Rollins DE, Maes RA, 1996).

Other Notes

N-methyl-N-trimethylsilylheptafluorobutyramide (MSHFBA) has been used in the silylation reaction during GC analysis of samples containing 1-monoolein, 2-monoolein, 1,2-diolein, 1,3-diolein, ethyl oleate, oleic acid and triolein.
Silylating agent for use in GC-analyses. It interferes least with flame-ionization detectors

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Warning

Hazard Statements

H226,H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

91.4 °F - closed cup

Flash Point(C)

33 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH3836
BCCC5184
BCBW8096
BCBS0963V
BCBN7822V

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Tobias Kieliba et al.
Drug testing and analysis, 11(2), 267-278 (2018-08-26)
The detection of Δ9 -tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) in hair, for the purpose of identifying cannabis consumption, is conducted in many forensic laboratories. Since external contamination of hair with these cannabis components cannot be excluded, even after
Matthias Zielonka et al.
Experimental neurology, 314, 91-99 (2019-01-18)
Acute hyperammonemic encephalopathy is a life-threatening manifestation of individuals with urea cycle disorders, which is associated with high mortality rates and severe neurological sequelae in survivors. Cerebral bioenergetic failure has been proposed as one of the key mechanisms underlying hyperammonemia-induced
Joris Probst et al.
Experimental neurology, 331, 113330-113330 (2020-04-28)
Chronic hyperammonemia is a common condition affecting individuals with inherited urea cycle disorders resulting in progressive cognitive impairment and behavioral abnormalities. Altered neurotransmission has been proposed as major source of neuronal dysfunction during chronic hyperammonemia, but the molecular pathomechanism has
J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
Heiko Brennenstuhl et al.
Molecular genetics and metabolism, 131(1-2), 163-170 (2020-07-18)
Aromatic L-amino acid decarboxylase (AADC) deficiency is a primary neurotransmitter defect of the biosynthesis of catecholamines and serotonin. The phenotype consists of varying degrees of neurological impairment, including motor and non-motor symptoms. Treatment outcomes correlate with the time point of
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