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870202O

Avanti

18:1 PDP PE

Avanti Research™ - A Croda Brand 870202O

Synonym(s):

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[3-(2-pyridyldithio)propionate] (sodium salt)

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About This Item

Empirical Formula (Hill Notation):
C49H84N2O9PNaS2
CAS Number:
474944-13-3
Molecular Weight:
963.29
UNSPSC Code:
12352211
NACRES:
NA.25

form

liquid

packaging

pkg of 1 × 25 mg (870202O-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 870202O

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(CCSSC1=CC=CC=N1)=O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Na+]

InChI

1S/C49H85N2O9PS2.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-36-48(53)57-43-45(60-49(54)37-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)44-59-61(55,56)58-41-40-50-46(52)38-42-62-63-47-35-33-34-39-51-47;/h17-20,33-35,39,45H,3-16,21-32,36-38,40-44H2,1-2H3,(H,50,52)(H,55,56);/q;+1/p-1/b19-17-,20-18-;/t45-;/m1./s1

InChI key

LFMWVVNPVNIPJG-JQRYTBKHSA-M

General description

18:1 PDP PE, also referred as 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[3-(2-pyridyldithio)propionate], is a head group modified functionalized lipid. Functionalized lipids mainly act as reporter molecules.

Application

18:1 PDP PE may be used in the preparation of hydrophobized disulfide-linked oligodeoxyribonucleotide (ODN). It may also be used in the preparation of liposomes.

Packaging

5 mL Clear Glass Sealed Ampule (870202O-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Disulfide-linked liposomes: effective delivery vehicle for Bcl-2 antisense oligodeoxyribonucleotide G3139
Weecharangsan W, et al.
Anticancer Research, 30(1), 31-37 (2010)
Laura Wayteck et al.
Biomaterials, 77, 243-254 (2015-11-26)
Following intravenous injection of anti-cancer nanomedicines, many barriers need to be overcome en route to the tumor. Cell-mediated delivery of nanoparticles (NPs) is promising in terms of overcoming several of these barriers based on the tumoritropic migratory properties of particular
Pathways for modulating exosome lipids identified by high-density lipoprotein-like nanoparticle binding to scavenger receptor type B-1
Angeloni NL, et al.
Scientific reports, 6(1) (2016)
Hitchhiking nanoparticles: Reversible coupling of lipid-based nanoparticles to cytotoxic T lymphocytes
Wayteck L, et al.
Biomaterials, 77, 243-254 (2016)
Wanlop Weecharangsan et al.
Anticancer research, 30(1), 31-37 (2010-02-13)
Disulfide-linked oligodeoxyribonucleotide (ODN) liposomes were formulated and evaluated for the delivery of antisense ODN G3139 in KB human oral carcinoma cells. Liposomes composed of 1,2-di-(9Z-octadecenoyl)-3-trimethylammo-nium-propane (DOTAP)/egg phosphatidylcholine/alpha-tocopheryl polyethylene glycol 1000 succinate were incorporated with hydrophobized disulfide-linked ODN. Disulfide-linked ODN liposomes
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