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Key Documents

850150P

Avanti

18:1 PI(3)P

Avanti Research - A Croda Brand

Synonym(s):

PIP[3′](18:1/18:1)

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About This Item

Empirical Formula (Hill Notation):
C45H90N2O16P2
CAS Number:
Molecular Weight:
977.15
UNSPSC Code:
51191904
NACRES:
NA.25

description

1,2-dioleoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′-phosphate) (ammonium salt)

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (with stopper and crimp cap (850150P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850150P-500ug))

manufacturer/tradename

Avanti Research - A Croda Brand

lipid type

cardiolipins
phospholipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OP([O-])(O)=O)[C@H]1O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+].[NH4+]

General description

Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.
Phosphatidylinositol phosphate is present in the plasma membrane.

Application

18:1 PIP has been used in liposome preparation. It may also be used to generate small unilamellar vesicles for liposome flotation assays.

Biochem/physiol Actions

Phosphatidylinositol phosphate helps to promote the plasma membrane H+-ATPase of Saccharomyces cerevisiae. Phosphatidylinositol 3-phosphate (PtdIns3P) is very essential for the biogenesis of autophagosomes and their precursors.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850150P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850150P-500ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion
Dolat L and Spiliotis ET
The Journal of Cell Biology, 214(5), 517-527 (2016)
Mariko Yokogawa et al.
The Journal of biological chemistry, 287(42), 34936-34945 (2012-08-24)
Phosphoinositides (PIs) are crucial lipid components of membranes and are involved in a number of cellular processes through interactions with their effector proteins. Recently, we have established a lipid-protein nanoscale bilayer (nanodisc) containing PIs, hereafter referred to as PI-nanodisc and
Richard J Chi et al.
The Journal of cell biology, 204(5), 793-806 (2014-02-26)
Retromer is an endosomal sorting device that orchestrates capture and packaging of cargo into transport carriers coated with sorting nexin BAR domain proteins (SNX-BARs). We report that fission of retromer SNX-BAR-coated tubules from yeast endosomes is promoted by Vps1, a
Etienne Morel et al.
Nature communications, 4, 2250-2250 (2013-08-03)
Defects in endosomal sorting have been implicated in Alzheimer's disease. Endosomal traffic is largely controlled by phosphatidylinositol-3-phosphate, a phosphoinositide synthesized primarily by lipid kinase Vps34. Here we show that phosphatidylinositol-3-phosphate is selectively deficient in brain tissue from humans with Alzheimer's
Qualitative and quantitative characterization of protein-phosphoinositide interactions with liposome-based methods
Busse RA, et al.
Autophagy, 9(5), 770-777 (2013)

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