Authenticated Colorectal Cancer Cell Lines for Cancer Research
Colorectal cancer (CRC) is the second most common cancer in women, and the third most common in men. For statistics combining men and women, CRC is the fourth leading cause of cancer mortality. More than half of the CRC cases reported are in developed countries, with the incidence increasing in developing countries. Colorectal cancer accounts for 10% of cancer-related deaths in western countries. Despite innovative therapeutic advances, mortality rates for colorectal cancer patients remains high1.
Types of cancer
Most colorectal cancers are classified as adenocarcinomas. Other, less common, types include gastrointestinal stromal tumor (GIST), carcinoid or neuroendocrine tumors, small cell carcinomas, and lymphomas, which typically start in cells of the immune system, but can also arise in other organs such as the colon or rectum1.
Cancer cell panels listed below are derived from adenocarcinoma.
Risk factors
Etiology and risk factors are both genetic and environmental. There is an increase in the incidence of colorectal cancer if first-degree family members are positive for the disease1. Lifestyle factors like smoking, alcohol consumption and obesity also increase the incidence of colorectal cancer.
Mutations
The most common genes altered (mutations with frequency >30%) in colorectal cancer includes APC, TP53, ERBB2, KRAS, PTEN, and BRAF.
Choose cell lines from the table below based on mutation, and click genes to find relevant products (antibodies, shRNA, siRNA, primers, CRISPR plasmids) for your research study.
Small molecules/monoclonal antibodies
Small molecule compounds and antibodies can be used to target specific cancer cells and block tumor growth and progression. The most common drugs used to target colorectal cancer include:
- 5-Fluorouracil
- Capecitabine
- Irinotecan
- Oxaliplatin
- Trifluridine and tipiracil (combination)
Applications
Cancer cell lines are the foundation for cancer research, and provide an accessible, cost-effective model for cellular behavior and response. Based on the characteristics of the cell line and experimental need, cell lines may be used in one or more applications. Some examples of application-specific cell line use are included below.
References
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