SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.

SAV1 promotes Hippo kinase activation through antagonizing the PP2A phosphatase STRIPAK.

eLife (2017-10-25)

Sung Jun Bae, Lisheng Ni, Adam Osinski, Diana R Tomchick, Chad A Brautigam, Xuelian Luo

摘要

The Hippo pathway controls tissue growth and homeostasis through a central MST-LATS kinase cascade. The scaffold protein SAV1 promotes the activation of this kinase cascade, but the molecular mechanisms remain unknown. Here, we discover SAV1-mediated inhibition of the PP2A complex STRIPAK

材料

货号

品牌

产品描述

F1804

Sigma-Aldrich

单克隆抗-FLAG^® M2 小鼠抗, 1 mg/mL, clone M2, affinity isolated antibody, buffered aqueous solution (50% glycerol, 10 mM sodium phosphate, and 150 mM NaCl, pH 7.4)

C1821

Sigma-Aldrich

抗-泛钙粘蛋白单克隆抗体小鼠抗, clone CH-19, ascites fluid