- Obstruction of BRAF
Obstruction of BRAF
Cancer gene therapy (2017-09-25)
J H Rothman, O Surriga, E de Stanchina, S D Vasudeva, G K Schwartz
PMID28937091
摘要
Peptide nucleic acid (PNA) oligomers are DNA mimics, which are capable of binding gene sequences 1000-fold more avidly than complementary native DNA by strand invasion and effectively obstruct transcription. Irreversibly obstructing the transcription or replication of a gene sequence, such as BRAF