- miR-21-mediated Radioresistance Occurs via Promoting Repair of DNA Double Strand Breaks.
miR-21-mediated Radioresistance Occurs via Promoting Repair of DNA Double Strand Breaks.
The Journal of biological chemistry (2017-01-18)
Baocheng Hu, Xiang Wang, Shuofeng Hu, Xiaomin Ying, Ping Wang, Xiangming Zhang, Jian Wang, Hongyan Wang, Ya Wang
PMID28096467
摘要
miR-21, as an oncogene that overexpresses in most human tumors, is involved in radioresistance; however, the mechanism remains unclear. Here, we demonstrate that miR-21-mediated radioresistance occurs through promoting repair of DNA double strand breaks, which includes facilitating both non-homologous end-joining (NHEJ) and homologous recombination repair (HRR). The miR-21-promoted NHEJ occurs through targeting
材料