- Mechanosensitive transient receptor potential vanilloid 4 regulates
Mechanosensitive transient receptor potential vanilloid 4 regulates
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2017-01-12)
Farai Gombedza, Vinay Kondeti, Nosayba Al-Azzam, Stephanie Koppes, Ernest Duah, Prachi Patil, Madison Hexter, Daniel Phillips, Charles K Thodeti, Sailaja Paruchuri
PMID28073835
摘要
Contributions of mechanical signals to airway remodeling during asthma are poorly understood. Transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion channel, has been implicated in cardiac and pulmonary fibrosis; however, its role in asthma remains elusive. Employing a