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A novel self-assembled sandwich nanomedicine for NIR-responsive release of NO.

A novel self-assembled sandwich nanomedicine for NIR-responsive release of NO.

Nanoscale (2015-11-17)

Jing Fan, Nongyue He, Qianjun He, Yi Liu, Ying Ma, Xiao Fu, Yijing Liu, Peng Huang, Xiaoyuan Chen

摘要

A novel sandwich nanomedicine (GO-BNN6) for near-infrared (NIR) light responsive release of nitric oxide (NO) has been constructed by self-assembly of graphene oxide (GO) nanosheets and a NO donor BNN6 through the π-π stacking interaction. The GO-BNN6 nanomedicine has an extraordinarily high drug loading capacity (1.2 mg BNN6 per mg GO), good thermal stability, and high NIR responsiveness. The NO release from GO-BNN6 can be easily triggered and effectively controlled by adjusting the switching, irradiation time and power density of NIR laser. The intracellular NIR-responsive release of NO from the GO-BNN6 nanomedicine causes a remarkable anti-cancer effect.

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纯乙醇, for molecular biology

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亚硝酸钠, ReagentPlus^®, ≥99.0%

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