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  • [Relative binding activity of dydrogesterone with blood mononuclear cells progesterone receptors of women included in the IVF program].

[Relative binding activity of dydrogesterone with blood mononuclear cells progesterone receptors of women included in the IVF program].

Eksperimental'naia i klinicheskaia farmakologiia (2013-09-07)
M V Suknovalova, L Kh Bekhbudova, M P Klimenko, L M Kappusheva, E N Kareva, N L Shimanovskiĭ, G M Savel'eva
摘要

It has been shown that specific binding of dydrogesterone with progesterone receptors in blood mononuclear cells of the patients included in the programs of in vitro fertilization, varies from 0 to 298%, thus at 38% of women dydrogesterone concedes to a progesterone in the competition for receptors of a progesterone, and 62%--exceed. The revealed variations of specific binding dydrogesterone with receptors of a progesterone are a reserve of increase of efficiency of auxiliary reproductive technology at the expense of individual selection of hormonal agents.

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Dydrogesterone, European Pharmacopoeia (EP) Reference Standard
Dydrogesterone impurity B, European Pharmacopoeia (EP) Reference Standard