Development of small-molecule inhibitors targeting adipose triglyceride lipase.

Development of small-molecule inhibitors targeting adipose triglyceride lipase.

Nature chemical biology (2013-10-08)

Nicole Mayer, Martina Schweiger, Matthias Romauch, Gernot F Grabner, Thomas O Eichmann, Elisabeth Fuchs, Jakov Ivkovic, Christoph Heier, Irina Mrak, Achim Lass, Gerald Höfler, Christian Fledelius, Rudolf Zechner, Robert Zimmermann, Rolf Breinbauer

PMID24096302

摘要

Adipose triglyceride lipase (ATGL) is rate limiting in the mobilization of fatty acids from cellular triglyceride stores. This central role in lipolysis marks ATGL as an interesting pharmacological target as deregulated fatty acid metabolism is closely linked to dyslipidemic and metabolic disorders. Here we report on the development and characterization of a small-molecule inhibitor of ATGL. Atglistatin is selective for ATGL and reduces fatty acid mobilization in vitro and in vivo.

材料

货号

品牌

产品描述

E3019

Sigma-Aldrich

酯酶来源于猪肝脏, lyophilized powder, ≥15 units/mg solid

E2884

Sigma-Aldrich

酯酶来源于猪肝脏, ammonium sulfate suspension, ≥150 units/mg protein (biuret)

96667

Sigma-Aldrich