- Synthesis of an AZT-HEPT hybrid and homologous AzddU derivatives.
Synthesis of an AZT-HEPT hybrid and homologous AzddU derivatives.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989) (1996-05-01)
E Larsen, K Danel, G B Vaaben, A A el-Emam, E B Pedersen, C Nielsen
PMID8634184
摘要
3'-Azido-2',3'-dideoxyuridines 6 and their corresponding alpha anomers 5 were synthesized by condensation of silylated 6-alkyl and 5,6-dialkyl substituted uracils 2 with methyl 3-azido-5-O-tert-butyldiphenylsilyl-2,3-dideoxy-alpha, beta-D-erythro-pentofuranoside (4). Compounds 5 and 6 were treated with tetrabutylammonium fluoride to obtain the deprotected nucleosides 7 and 8, respectively.