- Cymantrene conjugation modulates the intracellular distribution and induces high cytotoxicity of a cell-penetrating peptide.
Cymantrene conjugation modulates the intracellular distribution and induces high cytotoxicity of a cell-penetrating peptide.
Chemical communications (Cambridge, England) (2008-11-11)
Ines Neundorf, Jan Hoyer, Katrin Splith, Robert Rennert, Harmel W Peindy N'dongo, Ulrich Schatzschneider
PMID18997966
摘要
The conjugation of cymantrene CpMn(CO)(3) to cell-penetrating peptide hCT(18-32)-k7 alters the intracellular distribution in MCF-7 cells compared to the unmodified peptide, as visualized by fluorescence microscopy, and leads to an increased nuclear accumulation; the peptide and cymantrene compound themselves are not toxic, but the bioconjugate shows a significant cytotoxicity with an IC(50) value of 36 micromol l(-1).
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