- Antiproliferative activity of epi-cercosporin in human solid tumor cell lines.
Antiproliferative activity of epi-cercosporin in human solid tumor cell lines.
Natural product communications (2013-03-22)
Angel Trigos, César Espinoza, Maricela Martínez, Olivia Márquez, Leticia G León, José M Padrón, Manuel Norted, José J Fernández
PMID23513725
摘要
From cultures of Cercospora piaropi, a phytopathogenic fungus isolated from symptomatic leaves of water hyacinth was obtained a red compound, which, according to the spectroscopic data, was epi-cercosporin. It showed in vitro antiproliferative activity against the panel of human solid tumor cells HBL-100, HeLa, SW1573 and WiDr. Cell cycle studies revealed that epi-cercosporin induces accumulation of cells in G2/M phase.