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Merck
  • Synthesis of gamma-methyl-L-leucine (neopentylglycine, Neo) and derivatives suitable for peptide synthesis.

Synthesis of gamma-methyl-L-leucine (neopentylglycine, Neo) and derivatives suitable for peptide synthesis.

International journal of peptide and protein research (1981-09-01)
J L Fauchère, C Petermann
摘要

The modified Strecker synthesis of Patel & Worsley was combined with an enzymatic deamidation in the final step, to produce the title compound. The amino acid is a member of the family of the "fat" amino-acids with high lipophilicity and space-filling properties, as estimated by its Hansch hydrophobicity constant pi and its Charton steric parameter v. It can be used for qualitative and quantitative studies of structure-activity relationships in biologically active peptides. Three of its derivatives suitable for peptide synthesis are also described.

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Sigma-Aldrich
L-α-新戊基甘氨酸, ≥98.0% (TLC)