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Merck
  • Cellular uptake of covalent poly(allylamine hydrochloride) microcapsules and its influences on cell functions.

Cellular uptake of covalent poly(allylamine hydrochloride) microcapsules and its influences on cell functions.

Macromolecular bioscience (2012-09-26)
Bing Wang, Yuying Zhang, Zhengwei Mao, Changyou Gao
摘要

The mechanism of the cellular uptake of polyelectrolyte microcapsules and its influences on the functions and toxicity of human SMCs are explored. The covalently assembled poly(allylamine hydrochloride)/glutaraldehyde microcapsules are easily ingested by SMCs mainly through macropinosis and caveolae-mediated endocytosis pathways. The capsules mainly disperse in cytoplasm without colocalization in early endosomes and cell nucleus. The results of gene chips reveal substantial and profound alternation of cell phenotypes and functions. Uptake of the microcapsules cause a slight decrease of cell viability, but leads to significant changes in cytoskeleton organization, cell cycle, as well as cell adhesion and migration ability.

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Sigma-Aldrich
聚烯丙基胺盐酸盐, average Mw 50,000
价格与库存信息目前不能提供
Sigma-Aldrich
聚丙烯胺 溶液, 20 wt. % in H2O
价格与库存信息目前不能提供
Sigma-Aldrich
聚烯丙基胺盐酸盐, average Mw ~17,500 (GPC vs. PEG std.)
价格与库存信息目前不能提供
Sigma-Aldrich
聚丙烯胺 溶液, average Mw ~65,000, 10 wt. % in H2O
价格与库存信息目前不能提供