- Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes.
Room temperature palladium catalysed coupling of acyl chlorides with terminal alkynes.
Chemical communications (Cambridge, England) (2005-02-19)
Russell J Cox, Dougal J Ritson, Thomas A Dane, John Berge, Jonathan P H Charmant, Anob Kantacha
PMID15719108
摘要
Conditions are reported for the facile, high-yielding coupling of acyl chlorides with terminal alkynes in a reaction involving palladium and copper iodide; the reaction is tolerant of a wide variety of acyl chlorides and terminal alkynes and provides a convenient one-pot route to acetylenic ketones.