- Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma.
Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma.
European journal of medicinal chemistry (2010-02-02)
Cedric S Graebin, Maria de F Madeira, Jenicer K U Yokoyama-Yasunaka, Danilo C Miguel, Silvia R B Uliana, Diego Benitez, Hugo Cerecetto, Mercedes González, Ricardo Gomes da Rosa, Vera Lucia Eifler-Lima
PMID20116908
摘要
The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than the standard drug pentamidine. Additionally, we have identified two promising new anti-T. cruzi limonene derivatives.