- Radiosynthesis of 18F-fluoroethylated tracers via a simplified one-pot 18F-fluoroethylation method using [18F]fluoroethyl tosylate.
Radiosynthesis of 18F-fluoroethylated tracers via a simplified one-pot 18F-fluoroethylation method using [18F]fluoroethyl tosylate.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2021-01-08)
Kazunori Kawamura, Katsushi Kumata, Wakana Mori, Masayuki Fujinaga, Yusuke Kurihara, Masanao Ogawa, Takayuki Ohkubo, Kenji Furutsuka, Hiroki Hashimoto, Nobuki Nengaki, Ming-Rong Zhang
PMID33412382
摘要
Recently, a straightforward one-pot method for 18F-fluoroethylation without azeotropic drying of cyclotron-produced [18F]F- was developed. In this study, we have attempted to simplify the automated radiosynthesis of two [18F]fluoroethylated tracers, [18F]FEDAC and [18F]FET, using a desmethyl labeling precursor and [18F]fluoroethyl tosylate, based on the above-mentioned method. The radiochemical yields of [18F]FEDAC and [18F]FET were 26 ± 3.7% (n = 5) and 14 ± 2.2% (n = 4), respectively, based on total [18F]F- at the end of irradiation.
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