- Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.
Characterization of β-d-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.
Antimicrobial agents and chemotherapy (2017-02-01)
Maryam Ehteshami, Sijia Tao, Keivan Zandi, Hui-Mien Hsiao, Yong Jiang, Emily Hammond, Franck Amblard, Olivia O Russell, Andres Merits, Raymond F Schinazi
PMID28137799
摘要
Chikungunya virus (CHIKV) represents a reemerging global threat to human health. Recent outbreaks across Asia, Europe, Africa, and the Caribbean have prompted renewed scientific interest in this mosquito-borne alphavirus. There are currently no vaccines against CHIKV, and treatment has been limited to nonspecific antiviral agents, with suboptimal outcomes. Herein, we have identified β-d-N4-hydroxycytidine (NHC) as a novel inhibitor of CHIKV. NHC behaves as a pyrimidine ribonucleoside and selectively inhibits CHIKV replication in cell culture.
材料