SMILES字符串
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34CO)[C@@H]1CCC2=O
InChI
1S/C19H26O3/c1-18-8-7-16-14(15(18)4-5-17(18)22)3-2-12-10-13(21)6-9-19(12,16)11-20/h10,14-16,20H,2-9,11H2,1H3/t14-,15-,16-,18-,19+/m0/s1
InChI key
XGUHPTGEXRHMQQ-BGJMDTOESA-N
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[Hypertensinogenic steroid].
M Soma et al.
Nihon rinsho. Japanese journal of clinical medicine, 47(9), 2104-2108 (1989-09-01)
J P Weniger et al.
Reproduction, nutrition, development, 30(2), 253-257 (1990-01-01)
Aromatase activity in the foetal rat testis was demonstrated by the conversion of [3H] testosterone into oestradiol. However, the conversion rate was low, around 0.06%, probably because the radioactive precursor was heavily diluted by the large amounts of endogenous testosterone
H Sekihara et al.
The Journal of endocrinology, 138(1), 31-40 (1993-07-01)
We have reported that 19-hydroxyandrostenedione (19-OH-A-dione) amplifies the sodium-retaining action of aldosterone. To evaluate whether it also amplifies the hypertensive action of small doses of aldosterone, mononephrectomized rats were given 0.5 mg aldosterone, 10 mg 19-OH-A-dione or a combination of
D J McRobie et al.
The Journal of steroid biochemistry and molecular biology, 63(1-3), 147-153 (1998-02-04)
Diabetes complicates 2-3% of all pregnancies and is associated with an increase in both perinatal morbidity and mortality, though reasons for these adverse outcomes are unknown. Estrogen biosynthesis is a critical factor during pregnancy and is carried out in the
H Murase et al.
The Journal of steroid biochemistry and molecular biology, 38(3), 331-337 (1991-03-01)
To verify the aldosterone amplifying action of 19-hydroxyandrostenedione (19-OH-AD), we investigated [3H]aldosterone and [3H]19-OH-AD binding to type I (mineralocorticoid) receptor in the renal cytosol of adrenalectomized and ovariectomized rat, and human mononuclear leucocytes (MNL). In the [3H]aldosterone binding study, the
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