C9124

CK-869

≥98% (HPLC)

• 别名: 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone, CK 869, CK-0157869
• 经验公式（希尔记法）: C₁₇H₁₆BrNO₃S
• CAS号: 388592-44-7
• 分子量: 394.28
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to light gray
• 溶解度: DMSO: 10 mg/mL, clear
• 儲存溫度: 2-8°C
• InChI: 1S/C17H16BrNO3S/c1-21-13-6-7-14(15(9-13)22-2)19-16(20)10-23-17(19)11-4-3-5-12(18)8-11/h3-9,17H,10H2,1-2H3
• InChI 密鑰: MVWNPZYLNLATCH-UHFFFAOYSA-N

说明

應用

CK-869 has been used as an Arp2/3 complex inhibitor:

• to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
• to induce membrane blebbing in HT1080 fibrosarcoma cells
• to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis

生化／生理作用

CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.

CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast. The actin-related protein Arp2/3 complex plays a major role in the regulation of the actin cytoskeleton. Apparently the compound binds to the hydrophobic core of Arp3 and alters its conformation.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable