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Merck
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主要文件

5.04466

Sigma-Aldrich

LY-404,039

别名:

LY-404,039, (1R,4S,5S,6S)-4-[[(2S)-2-Amino-4-(methylthio)-1-oxobutyl]amino]-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide

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About This Item

经验公式(希尔记法):
C7H9NO6S
分子量:
235.21
分類程式碼代碼:
12352200

化驗

≥98% (NMR)

品質等級

形狀

powder

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

white

溶解度

DMSO: 0.25 mg/mL
dilute NaOH: 10 mg/mL

儲存溫度

−20°C

InChI

1S/C12H18N2O7S2/c1-22-3-2-5(13)9(15)14-12(11(18)19)4-23(20,21)8-6(7(8)12)10(16)17/h5-8H,2-4,13H2,1H3,(H,14,15)(H,16,17)(H,18,19)/t5-,6+,7+,8-,12+/m0/s1

InChI 密鑰

VOYCNOJFAJAILW-OZFRBSTCSA-N

一般說明

A highly selective and potent agonist for recombinant human mGlu2 and mGlu3 receptors (Ki = 149 nM and 92 nM, respectively) and for rat neurons mGlu2/3 receptors (Ki = 88 nM). Negligible interactions with other mGlu receptors and ionotropic glutamate receptors, glutamate transporter subtypes, monoamine and other receptors. Widely used for investigating neuropsychiatric disorders in animal models and developing potential treatment for human mental disorders, such as schizophrenia.

生化/生理作用

Primary Target
mGlu₂ & mGlu₃
Target Ki: 149 nM and 92 nM for human mGlu₂ and mGlu₃, respectively.

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months ta -20°C.

其他說明

Seeman, P., 2013. Neuropharmacology.66, 87.
Rorick-Kehn, L., et al. 2007. J. Pharmacol. Exp. Ther.321, 308.
Fell, M., et al. 2008. J. Pharmacol. Exp. Ther.326, 209.
Rodd, Z., et al. 2006. Behav. Brain Res.171, 207.
Mezler, M., et al. 2010. Curr. Opi. In Investigational Drugs.11, 833.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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