跳转至内容
Merck

TEK

TEK tyrosine kinase, endothelial

别名:
CD202B, TIE-2, TIE2, VMCM, VMCM1
物种:
Human TEK (7010), Mouse Tek (21687), Rat Tek (89804), chicken TEK (427368), Zebrafish tek (30747), dog TEK (403714), domestic cat TEK (101091977), cow TEK (280939), domestic guinea pig Tek (100713324), naked mole-rat Tek (101710501)
UniProtKB ID:
Q02763, A8K6W0, B4DH20, B4DHD3, D3DRK5, E7EWI2, Q5TCU2, Q8IV34
基因ID:
  • Human(7010) Summary: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq, Jul 2008]
  • Mouse(21687) endothelial-specific receptor tyrosine kinase
  • Rat(89804) TEK tyrosine kinase, endothelial
  • chicken(427368) TEK tyrosine kinase, endothelial
  • Zebrafish(30747) TEK tyrosine kinase, endothelial
  • dog(403714) TEK tyrosine kinase, endothelial
  • domestic cat(101091977) TEK tyrosine kinase, endothelial
  • cow(280939) TEK tyrosine kinase, endothelial
  • domestic guinea pig(100713324) TEK tyrosine kinase, endothelial
  • naked mole-rat(101710501) TEK tyrosine kinase, endothelial

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

ELISA

货号
说明
物种
RAB0457
人类 Tie-2 ELISA试剂盒, for serum, plasma, cell culture supernatants and urine,
物种
human
RAB1930
大鼠Tie-2 ELISA, for serum, plasma and cell culture supernatants,
物种
rat
RAB1002
磷酸酪氨酸TEK /血管生成素1受体ELISA试剂盒, ,
物种
human

Antibodies

货号
说明
物种反应性
应用
05-584
抗-Tie2/TEK抗体，克隆Ab33, clone Ab33, Upstate®, from mouse,
物种反应性
human, mouse, pig, rat
应用
immunohistochemistry
immunoprecipitation (IP)
western blot
SAB4503999
抗-磷酸-TIE2 (pTyr1108) 兔抗, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
western blot
ABF131
Anti-phospho TIE2/TEK Antibody (Tyr992), 0.25 mg/mL, from rabbit,
物种反应性
bovine, human, mouse, rat, zebrafish
应用
immunoprecipitation (IP)
inhibition assay
western blot
SAB1412265
ANTI-TEK antibody produced in mouse, clone 4G9, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
ZRB1645
Anti-Tie-2 Antibody, clone 1C5 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
bovine, canine, human, monkey, mouse, rat
应用
affinity binding assay
immunocytochemistry
western blot

Small Molecule - Inhibitor

货号
说明
物种
C8863
7-Cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3‑d]pyrimidin-4-ylamine, ≥98% (HPLC),
物种
human

Proteins

货号
说明
物种
14-540-M
Tie2 Protein, active, 10 µg, Active, N-terminal His6-tagged recombinant human Tie2 residues 771-end, for use in Kinase Assays.,
物种
human
14-763-M
Tie2 (R849W) Protein, active, 250 µg, ,
物种
human
14-764-M
Tie2 (Y897S) Protein, active, ,
物种
human
SRP5092
TIE2 (771-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human

esiRNA

货号
说明
物种
EMU070911
MISSION® esiRNA, targeting mouse Tek,
物种
mouse
EHU082281
MISSION® esiRNA, targeting human TEK,
物种
human