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Merck

PRKCA

protein kinase C, alpha

别名:
AAG6, PKC-alpha, PKCA, PRKACA
物种:
UniProtKB ID:
基因ID:
  • Human(5578) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]
  • Mouse(18750) protein kinase C, alpha
  • Rat(24680) protein kinase C, alpha
  • Horse(100063318) protein kinase C, alpha
  • dog(490904) protein kinase C, alpha
  • Domestic Rabbit(100037720) protein kinase C, alpha
  • domestic cat(101086433) protein kinase C, alpha
  • sheep(101110074) protein kinase C, alpha
  • Zebrafish(497384) protein kinase C, alpha
  • chicken(417430) protein kinase C, alpha
  • cow(282001) protein kinase C, alpha
  • domestic guinea pig(100302324) protein kinase C, alpha
  • domestic guinea pig(100713627) protein kinase C, alpha
  • naked mole-rat(101716044) protein kinase C, alpha

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Small Molecule - Activator

货号
说明
物种
PKC Lipid Activator, ,
物种
human

Small Molecule - Agonist

货号
说明
物种
油酸, ≥99% (GC),
物种
human

Antibodies

货号
说明
物种反应性
应用
Anti-PKC α antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry

western blot
Anti-Protein kinase C antibody, Mouse monoclonal, clone MC5, purified from hybridoma cell culture,
物种反应性
bovine, chicken, fish, human, mouse, rabbit, rat
应用
immunocytochemistry
immunofluorescence

immunoprecipitation (IP)

western blot
Anti-PKC Antibody (α, β, γ), clone M110, clone M110, Upstate®, from mouse,
物种反应性
human, mouse, rat
应用
ELISA
immunocytochemistry

immunoprecipitation (IP)

western blot
Anti-PKC-PAN antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-PKC alpha Antibody, clone 1G10S8, Rabbit Monoclonal, ,
物种反应性
human, rat
应用
immunohistochemistry
immunoprecipitation (IP)

western blot

Small Molecule - Inhibitor

货号
说明
物种
D-鞘氨醇, synthetic,
物种
rat
1-油酰基-2-乙酰基-sn-丙三醇, ≥97% (TLC), oil,
物种
human
K-252a, Ready Made Solution, from Nonomuraea longicatena, >98%,
物种
rat, human
K-252a, from Nonomuraea longicatena, ≥98% (HPLC),
物种
rat, human
(S)-(+)-喜树碱, ≥90% (HPLC), powder,
物种
rat, mouse, human

Proteins

货号
说明
物种
PKCα Protein, active, 10 µg, Active, recombinant, full-length human PKCα, containing N-terminal His6 tag. For use in Kinase Assays.,
物种
human
Protein kinase Cα isozyme human, ≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution,
物种
human
PKC-α,活性,GST 标记 from Xanopus sp., PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting mouse Prkca,
物种
mouse
MISSION® esiRNA, targeting human PRKCA,
物种
human

Small Molecule - Substrate

货号
说明
物种
PKC Substrate Cocktail, ,
物种
human
PKC Substrate Peptide, PKC Substrate Peptide primarily used in Kinase Assays.,
物种
human