MAPK8
mitogen-activated protein kinase 8
别名:
JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c
物种:
Human MAPK8 (5599), Mouse Mapk8 (26419), Rat Mapk8 (116554), chicken MAPK8 (423778), cow MAPK8 (539941), Goat MAPK8 (100861087), domestic cat MAPK8 (101091310), Horse MAPK8 (100051798), dog MAPK8 (477746), Domestic Rabbit MAPK8 (100346929) ...展开
UniProtKB ID:
基因ID:
- Human(5599) Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]
- Mouse(26419) mitogen-activated protein kinase 8
- Rat(116554) mitogen-activated protein kinase 8
- chicken(423778) mitogen-activated protein kinase 8
- cow(539941) mitogen-activated protein kinase 8
- Goat(100861087) mitogen-activated protein kinase 8
- domestic cat(101091310) mitogen-activated protein kinase 8
- Horse(100051798) mitogen-activated protein kinase 8
- dog(477746) mitogen-activated protein kinase 8
- Domestic Rabbit(100346929) mitogen-activated protein kinase 8
- sheep(101116201) mitogen-activated protein kinase 8
- domestic guinea pig(100722333) mitogen-activated protein kinase 8
- naked mole-rat(101715259) mitogen-activated protein kinase 8
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Antibodies
产品编号
说明
物种反应性
应用
抗磷酸化-JNK (Thr183/Tyr185, Thr221/Tyr223) 抗体, from rabbit, purified by affinity chromatography,
物种反应性
xenopus, bovine, canine, chicken, equine, horse, human, mouse, rat
应用
activity assay
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
PhosphoDetect Anti-SAPK/JNK (pThr¹⁸³, Tyr¹⁸⁵) Rabbit pAb, liquid, Calbiochem®,
物种反应性
caenorhabditis elegans, drosophila, chicken, human, mouse, rat
应用
PhosphoDetect Anti-JNK1/2 (pThr¹⁸³/Tyr¹⁸⁵) Rabbit pAb, liquid, Calbiochem®,
物种反应性
human, mouse, rat
应用
Proteins
产品编号
说明
物种
JNK1α1/SAPK1c Protein, active, 10 µg, Active, recombinant full-length human JNK1α1/SAPK1c with an N-terminal His-tag, for use in Kinase Assays.,
物种
human
JNK1α1/SAPK1c Protein, inactive, 50 g, Unactive, N-terminal His6-tagged recombinant, human, full-length JNK1α1/SAPK1c, for use in Kinase Assays.,
物种
human