MAPK14
mitogen-activated protein kinase 14
别名:
CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA
物种:
Human MAPK14 (1432), Mouse Mapk14 (26416), Rat Mapk14 (81649), naked mole-rat Mapk14 (101715692), domestic guinea pig Mapk14 (100723285), chicken MAPK14 (421183), Horse MAPK14 (100063532), dog MAPK14 (403856), domestic cat MAPK14 (101101135), Domestic Rabbit MAPK14 (100341695) ...展开
UniProtKB ID:
基因ID:
- Human(1432) Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- Mouse(26416) mitogen-activated protein kinase 14
- Rat(81649) mitogen activated protein kinase 14
- naked mole-rat(101715692) mitogen-activated protein kinase 14
- domestic guinea pig(100723285) mitogen-activated protein kinase 14
- chicken(421183) mitogen-activated protein kinase 14
- Horse(100063532) mitogen-activated protein kinase 14
- dog(403856) mitogen-activated protein kinase 14
- domestic cat(101101135) mitogen-activated protein kinase 14
- Domestic Rabbit(100341695) mitogen-activated protein kinase 14
- sheep(100217411) mitogen-activated protein kinase 14
- cow(534492) mitogen-activated protein kinase 14
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Antibodies
产品编号
说明
物种反应性
应用
Anti-phospho-p38 (Thr180/Tyr182) Antibody, clone 6E5.2, clone 6E5.2, from mouse,
物种反应性
human, mouse
应用
immunocytochemistry
western blot
western blot
抗磷酸化p38 α（Thr180 / Tyr182）抗体, Upstate®, from rabbit,
物种反应性
human, mouse, rat
应用
immunoprecipitation (IP)
western blot
western blot
Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8, rabbit monoclonal, culture supernatant, clone 8.78.8, from rabbit,
物种反应性
human, mouse, vertebrates
应用
immunofluorescence
western blot
western blot
PhosphoDetect Anti-p38 MAP Kinase (pThr¹⁸⁰, pTyr¹⁸²) Rabbit pAb, liquid, Calbiochem®,
物种反应性
canine, human, mouse, rat
应用
Anti-p38/SAPK2 Antibody, clone 2F11, clone 2F11, from mouse,
物种反应性
human, mouse, rat
应用
western blot
Proteins
产品编号
说明
物种
p38α/SAPK2a Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant, full length p38α/SAPK2a, for use in Kinase Assays.,
物种
human
p38α/SAPK2a (T106M) Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human, full-length p38α/SAPK2a containing the mutation T106M. Activated using DD-MKK6 & repurified using glutathione-agarose. For use in Kinase Assays.,
物种
human