FAS
Fas cell surface death receptor
别名:
ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
物种:
Human FAS (355), Mouse Fas (14102), Rat Fas (246097), fruit fly fas (36521), Zebrafish fas (768248), chicken FAS (395274), dog FAS (486469), domestic cat FAS (493881), Horse FAS (100071639), cow FAS (282488) ...展开
UniProtKB ID:
基因ID:
- Human(355) Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]
- Mouse(14102) Fas (TNF receptor superfamily member 6)
- Rat(246097) Fas cell surface death receptor
- fruit fly(36521) faint sausage
- Zebrafish(768248) Fas (TNF receptor superfamily, member 6)
- chicken(395274) Fas (TNF receptor superfamily, member 6)
- dog(486469) Fas (TNF receptor superfamily, member 6)
- domestic cat(493881) Fas (TNF receptor superfamily, member 6)
- Horse(100071639) Fas (TNF receptor superfamily, member 6)
- cow(282488) Fas (TNF receptor superfamily, member 6)
- sheep(100144426) Fas (TNF receptor superfamily, member 6)
- Domestic Rabbit(100008609) Fas (TNF receptor superfamily, member 6)
- domestic guinea pig(100726403) Fas cell surface death receptor
- naked mole-rat(101704746) Fas cell surface death receptor
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ELISA
Antibodies
货号
说明
物种反应性
应用
抗-Fas 抗体（人，中和），克隆 ZB4, clone ZB4, Upstate®, from mouse,
物种反应性
human
应用
flow cytometry
neutralization
western blot
neutralization
western blot
抗-Fas抗体（人，激活），克隆CH11, clone CH11, Upstate®, from mouse,
物种反应性
human
应用
flow cytometry
immunocytochemistry
western blot
immunocytochemistry
western blot
抗-FAS 兔抗, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Fas Antibody, clone SM1/1, clone SM1/1, Chemicon®, from mouse,
物种反应性
human
应用
flow cytometry
Monoclonal Anti-Fas, clone DX2, purified from hybridoma cell culture,
物种反应性
human
应用
flow cytometry
microarray
microarray
Proteins
货号
说明
物种
Fas Intracellular Domain human, >90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution,
物种
human
FAS Receptor human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
物种
human
Fas/Fc Chimera from mouse, >97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture,
物种
mouse