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Merck

CDKN2A

cyclin-dependent kinase inhibitor 2A

别名:
ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16
物种:
Human CDKN2A (1029), Mouse Cdkn2a (12578), Rat Cdkn2a (25163), chicken CDKN2A (395077), dog CDKN2A (100271861), domestic guinea pig Cdkn2a (100731972), domestic cat CDKN2A (101089220), cow CDKN2A (616369)
UniProtKB ID:
P42771, A5X2G7, D3DRK1, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05
基因ID:
  • Human(1029) Summary: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
  • Mouse(12578) cyclin-dependent kinase inhibitor 2A
  • Rat(25163) cyclin-dependent kinase inhibitor 2A
  • chicken(395077) cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
  • dog(100271861) cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
  • domestic guinea pig(100731972) cyclin-dependent kinase inhibitor 2A
  • domestic cat(101089220) cyclin-dependent kinase inhibitor 2A
  • cow(616369) cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

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Antibodies

产品编号
说明
物种反应性
应用
MAB4133
抗-p16抗体，克隆D25, clone D25, Chemicon®, from mouse,
物种反应性
human
应用
immunohistochemistry
western blot
MABE1328
Anti-INK4a (p16) Antibody, clone 13H4.1, clone 13H4.1, from mouse,
物种反应性
human
应用
immunohistochemistry
western blot
ABC1430
Anti-p14ARF (p19ARF), from rabbit, purified by affinity chromatography,
物种反应性
human
应用
immunohistochemistry
immunoprecipitation (IP)
western blot
07-543
Anti-p19 ARF Antibody, Upstate®, from rabbit,
物种反应性
mouse, rat
应用
immunoprecipitation (IP)
western blot