BRCA2
breast cancer 2, early onset
别名:
BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2
物种:
Human BRCA2 (675), Mouse Brca2 (12190), Rat Brca2 (360254), domestic guinea pig Brca2 (100713136), Zebrafish brca2 (566758), naked mole-rat Brca2 (101698015), chicken BRCA2 (374139), sheep BRCA2 (101109980), fruit fly Brca2 (37916), cow BRCA2 (507069) ...展开
UniProtKB ID:
基因ID:
- Human(675) Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
- Mouse(12190) breast cancer 2
- Rat(360254) breast cancer 2, early onset
- domestic guinea pig(100713136) breast cancer 2, early onset
- Zebrafish(566758) breast cancer 2, early onset
- naked mole-rat(101698015) breast cancer 2, early onset
- chicken(374139) breast cancer 2, early onset
- sheep(101109980) breast cancer 2, early onset
- fruit fly(37916) Breast cancer 2, early onset homolog
- cow(507069) breast cancer 2, early onset
- dog(474180) breast cancer 2, early onset
- domestic cat(493878) breast cancer 2, early onset
- Horse(100064578) breast cancer 2, early onset
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Antibodies
货号
说明
物种反应性
应用
抗-BRCA2 兔抗, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
Anti-BRCA2 Antibody, clone 1H2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human
应用
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-BRCA2 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, rat
应用
ELISA
immunohistochemistry
immunohistochemistry
抗BRCA2抗体，克隆5.23, clone 5.23, Upstate®, from mouse,
物种反应性
human
应用
immunocytochemistry
western blot
western blot