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Merck

BRCA2

breast cancer 2, early onset

别名:
BRCC2, BROVCA2, FACD, FAD, FAD1, FANCB, FANCD, FANCD1, GLM3, PNCA2
物种:
Human BRCA2 (675), Mouse Brca2 (12190), Rat Brca2 (360254), domestic guinea pig Brca2 (100713136), Zebrafish brca2 (566758), naked mole-rat Brca2 (101698015), chicken BRCA2 (374139), sheep BRCA2 (101109980), fruit fly Brca2 (37916), cow BRCA2 (507069) ...展开
UniProtKB ID:
P51587, O00183, O15008, Q13879, Q5TBJ7
基因ID:
  • Human(675) Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
  • Mouse(12190) breast cancer 2
  • Rat(360254) breast cancer 2, early onset
  • domestic guinea pig(100713136) breast cancer 2, early onset
  • Zebrafish(566758) breast cancer 2, early onset
  • naked mole-rat(101698015) breast cancer 2, early onset
  • chicken(374139) breast cancer 2, early onset
  • sheep(101109980) breast cancer 2, early onset
  • fruit fly(37916) Breast cancer 2, early onset homolog
  • cow(507069) breast cancer 2, early onset
  • dog(474180) breast cancer 2, early onset
  • domestic cat(493878) breast cancer 2, early onset
  • Horse(100064578) breast cancer 2, early onset

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Antibodies

产品编号
说明
物种反应性
应用
OP95
抗-BRCA2 (Ab-1) 小鼠mAb (2B), liquid, clone 2B, Calbiochem®,
物种反应性
human
应用
05-666
抗BRCA2抗体，克隆5.23, clone 5.23, Upstate®, from mouse,
物种反应性
human
应用
immunocytochemistry
western blot
AB9986
抗磷酸化BRCA2（Ser3291）抗体, from rabbit, purified by affinity chromatography,
物种反应性
canine, cat, chimpanzee, equine, hamster, horse, human, mouse, rat, rhesus macaque, rhesus monkey
应用
dot blot
immunocytochemistry
immunohistochemistry