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U2500

Sigma-Aldrich

Urethane

≥99%

Synonym(s):

Carbamic acid ethyl ester, Ethyl carbamate, Ethylurethane

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About This Item

Linear Formula:
NH2COOC2H5
CAS Number:
51-79-6
Molecular Weight:
89.09
Beilstein:
635810
EC Number:
200-123-1
MDL number:
MFCD00007966
UNSPSC Code:
12352111
PubChem Substance ID:
24900632
NACRES:
NA.25

vapor density

3.07 (vs air)

vapor pressure

10 mmHg ( 77.8 °C)

Assay

≥99%

bp

182-184 °C (lit.)

mp

48-50 °C (lit.)

SMILES string

CCOC(N)=O

InChI

1S/C3H7NO2/c1-2-6-3(4)5/h2H2,1H3,(H2,4,5)

InChI key

JOYRKODLDBILNP-UHFFFAOYSA-N

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Application


  • Sex differences in cholinergic signaling affect functional outcomes for theta-gamma coordination in hippocampal subcircuits following experimental febrile status epilepticus.: This study uses urethane anesthesia to investigate the impact of sex differences on cholinergic signaling in the hippocampus, shedding light on neurological responses and potential therapeutic targets (Kloc et al., 2024).

  • Postinspiratory and preBötzinger complexes contribute to respiratory-sympathetic coupling in mice before and after chronic intermittent hypoxia.: Urethane is utilized in this study to explore respiratory and sympathetic nervous system interactions, providing insights into adaptive physiological mechanisms (Karlen-Amarante et al., 2024).

  • Instant clot forming and antibacterial wound dressings: Achieving hemostasis in trauma injuries with S-nitroso-N-acetylpenicillamine-tranexamic acid-propolis formulation.: This paper presents innovative urethane-based wound dressings that offer rapid clot formation and antibacterial properties, crucial for trauma care (Nguyen et al., 2024).

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H302,H350

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

197.6 °F - closed cup

Flash Point(C)

92 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Siqi Li et al.
Nature communications, 11(1), 1800-1800 (2020-04-15)
The environmental carcinogen urethane exhibits a profound specificity for pulmonary tumors driven by an oncogenic Q61L/R mutation in the gene Kras. Similarly, the frequency, isoform, position, and substitution of oncogenic RAS mutations are often unique to human cancers. To elucidate
M Khoshgoftar et al.
Journal of biomechanics, 48(8), 1427-1435 (2015-03-15)
Since meniscal geometry affects the cartilage contact pressures, it is essential to carefully define the geometry of the synthetic meniscal implant that we developed. Recently, six independent modes of size- and shape-related geometry variation were identified through 3D statistical shape
Aaron D Mickle et al.
Nature, 565(7739), 361-365 (2019-01-04)
The fast-growing field of bioelectronic medicine aims to develop engineered systems that can relieve clinical conditions by stimulating the peripheral nervous system1-5. This type of technology relies largely on electrical stimulation to provide neuromodulation of organ function or pain. One
C A Maggi et al.
Experientia, 42(3), 292-297 (1986-03-15)
Urethane produces a level of surgical anesthesia characterized by preservation of a number of cardiovascular reflexes. When the proper route of administration is used, and the use of unnecessarily high doses is avoided, urethane anesthesia appears to be suitable for
C A Maggi et al.
Experientia, 42(2), 109-114 (1986-02-15)
The suitability of urethane anesthesia for physiopharmacological investigations is reviewed. Total dose administered and route of administration are recognized as factors having a great influence on both resting parameters and biological responses to drugs. A peculiar characteristic of urethane is
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